The Seattle Mariners will look to win their eighth game in a row when they take on the Baltimore Orioles in a key American League matchup on Tuesday. Seattle is coming off a 6-3 win over Tampa Bay on Sunday, while Baltimore dropped a 3-2 decision to the Athletics. The Mariners (66-53), who are 9-1 in their past 10 games, are 29-28 on the road this season. The Orioles (53-65), who are fifth in the AL East, are 28-29 on their home field in 2025.
First pitch from Oriole Park at Camden Yards in Baltimore is set for 6:35 p.m. ET. The Orioles have won six of the past seven meetings with the Mariners. Seattle is a -158 favorite on the money line (risk $158 to win $100) in the latest Mariners vs. Orioles odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9. Before making any Mariners vs. Orioles picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model. New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 21 of the 2025 MLB season a profitable 31-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has set its sights on Mariners vs. Orioles and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Orioles vs. Mariners, which you can get in on with a DraftKings promo code or a FanDuel promo code.
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Mariners vs. Orioles money line |
Seattle -158, Baltimore +133 at DraftKings Sportsbook |
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Mariners vs. Orioles over/under |
9 runs |
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Mariners vs. Orioles run line |
Seattle -1.5 (+101) |
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Mariners vs. Orioles picks |
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Mariners vs. Orioles streaming |
Fubo (Try for free) |
Why the Mariners can win
Right-hander George Kirby (7-5, 4.04 ERA) is expected to take the mound for Seattle. In 14 games, all starts, he has pitched 78 innings, allowing 68 hits, 35 earned runs and 20 walks, while striking out 83. He has won six of his last seven starts, including an 8-6 triumph over the Chicago White Sox on Wednesday. He pitched six innings, allowing five hits, two earned runs and two walks, while striking out nine.
Among Seattle’s top offensive threats is catcher Cal Raleigh. In 116 games this season, he is hitting .247 with 16 doubles, 45 home runs, 98 RBI and 78 runs scored. He has a three-game hitting streak, homering in all three weekend games against the Tampa Bay Rays. In 20 career games against Baltimore, he is hitting .221 with four doubles, five homers and 16 RBI. He is 4-for-12 against the Orioles this season with one double, one homer and four RBI. See which team to back at SportsLine.
Why the Orioles can win
Baltimore is expected to start right-hander Dean Kremer (8-8, 4.35 ERA). In 23 games, including 22 starts, he has logged 132.1 innings, allowing 134 hits, 66 runs – 64 earned – and 35 walks, while striking out 110. He is coming off a 5-0 loss at Philadelphia on Aug. 5. In that game, he pitched six innings, allowing eight hits, four earned runs and one walk, while striking out six.
Shortstop Gunnar Henderson helps lead the Baltimore offense. He has hits in eight of 10 games, including four in a row. He was 3-for-9 with one home run and three RBI in the three-game weekend series against the Athletics. In a 4-3 win over the Chicago Cubs on Aug. 2, he was 2-for-4 with a homer, three RBI and one run scored. He was 2-for-5 with an RBI and two runs scored in a 9-8 loss to the Toronto Blue Jays on July 30. See which team to back at SportsLine.
How to make Mariners vs. Orioles picks
SportsLine’s model is leaning Over on the total, projecting 9.7 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins Mariners vs. Orioles, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.
