The 2025 MLB Playoffs are approaching quickly, but there are 16 regular-season matchups on Tuesday where new users can use BetMGM bonus code CBSSports to receive up to $1,500 back in bonus bets if your first bet loses or $150 in bonus bets if your first bet of at least $10 wins. That includes a crucial battle between the Diamondbacks and Giants at 9:40 p.m. ET. The two NL West rivals are both within two games of the Mets for the final NL Wild Card spot and that’s shaping up to be a four-team race with the Reds also two games back.
Arizona is the -125 favorite in the latest MLB odds for Tuesday, while the Giants are listed at +105, and the SportsLine Projection Model lists Arizona on the money line as one of its MLB best bets tonight. There’s also Champions League and the WNBA playoffs today. Before locking in your Tuesday MLB picks on your favorite betting sites like BetMGM Sportsbook, be sure to check out the rest of the top MLB betting picks from SportsLine’s proven computer model. Click here to get the newest BetMGM promo code and take advantage of one of the best sportsbook promos:
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 26 of the 2025 MLB season a profitable 34-27 on top-rated MLB money-line picks. It has also excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following its MLB predictions at sportsbooks and on betting apps could have seen strong returns.
Best Tuesday MLB picks at BetMGM Sportsbook:
Combining the model’s three picks into a Tuesday MLB parlay at BetMGM would result in a payout of +638 (risk $100 to win $638). Bet it at BetMGM here:
Cubs money line vs. Pirates (+110)
Paul Skenes is a staggering -10000 favorite to win NL Cy Young honors and enters Tuesday sporting a 1.92 ERA. However, the Pirates limited him to only 64 pitches despite the fact that he threw five innings of shutout ball in his last start and are now actively managing his workload. Pittsburgh went on to lose that game in extra innings and is now only 16-14 in Skenes starts. Meanwhile, the Cubs are in comfortable playoff position and will hand the ball to capable rookie Cade Horton, who is 10-4 with a 2.70 ERA over 110 innings. Horton has only given up three earned runs over his last four starts (22 1/3 innings) and that’s a big reason why Chicago wins in 54% of simulations.
Over 8 runs in White Sox vs. Orioles (-105)
Shane Smith has been Chicago’s best starting pitcher this season and Dean Kremer is among Baltimore’s most dependable options. However, neither have been dominant and both of these offenses have shown a little more life in the second half of the season. The White Sox posted a .639 OPS before the all-star break but have a team OPS of .741 since and the Orioles are up more modestly from .702 to .710. The model predicts 9.5 runs on average and that the over hits 58% of the time.
Diamondbacks money line vs. Giants (-125)
Arizona was a seller at the MLB trade deadline but still finds itself in the NL playoff picture and after an 8-1 win in Game 1 against the Giants on Monday, they have a chance to deal a crushing blow to one of the teams they’re vying with for a spot. Eduardo Rodriguez takes the ball for the Diamondbacks on Tuesday and he’s been stellar over his last three starts, allowing only one earned run and 10 hits over 18 1/3 innings. Meanwhile, the Giants appear in line for a bullpen day and that’s a big reason why the model has Arizona winning in 62% of simulations.
Want more MLB picks for Tuesday, September 16?
You’ve seen the model’s Tuesday MLB best bets. Now, get against the spread, total and money-line picks for MLB for the rest of the week, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Tuesday MLB picks from legendary handicapper Bruce Marshall, who is 147-131-3 (+2951) over his last 281 MLB picks. He’s already locked in a couple of MLB picks for tonight. See his best bets right here.
