We’re on to Week 3 of the 2025 NFL season, injuries are starting to pile up. That’s especially true at quarterback, where a handful of notable starters are out this week and could miss even more time moving forward. If you’re interested in NFL betting, you need to be aware of who’s in and who’s out before you place any wagers at top sportsbooks.
Here, we break down the biggest NFL injuries to know for all of the Week 3 games on Sunday and Monday, including how lines have shifted according to the latest SportsLine consensus odds, which uses the latest data and odds from top sportsbooks. This post will be updated as official inactives lists are announced before kickoff.
Atlanta Falcons at Carolina Panthers (1 p.m. ET)
The Panthers are looking to avoid an 0-3 start when they host the Falcons, and they are beat up on the offensive line with not one, but two starters heading to injured reserve this week. That unit has quietly been a bright spot for a Carolina team that, quite frankly, has been among the league’s worst over the last few seasons.
As for the Falcons, the biggest injury to note is top cornerback AJ Terrell will be out of action, which is good news for Panthers quarterback Bryce Young and rookie receiver Tetairoa McMillan. Young will not have receiver Xavier Legette, however, as he’s out with a hamstring injury.
Things have moved Atlanta’s way here, with the Falcons now favored by 5.5 points after opening at -1.5. The total is also down to 43.5 after opening at 46.5.
Green Bay Packers at Cleveland Browns (1 p.m. ET)
The biggest injury news heading into this matchup was Green Bay tight end Tucker Kraft listed as questionable with a knee injury after a 100-yard Week 2 showing. He is active against Cleveland, as is Packers left tackle Zach Tom. Receiver Jayden Reed is out.
The Packers are 7.5-point favorites on the road and the total is 41.5.
Houston Texans at Jacksonville Jaguars (1 p.m. ET)
- No notable injuries for either team
The Jags have listed starting guard Ezra Cleveland as questionable, but that’s the biggest piece of injury news as far as who’s banged up for this AFC South tilt. The good news here is Christian Kirk is set to make his Texans debut after missing Weeks 1 and 2 with a hamstring injury. Kirk will make his 2025 debut against the Jaguars, where he played the last three years and had over 1,100 yards in 2022.
The Jags are favored by 1.5 after opening at -2, and the total is now 43.5 after opening at 44.5.
Cincinnati Bengals at Minnesota Vikings (1 p.m. ET)
Both teams are without their starting quarterbacks as Joe Burrow is out for most of 2025 due to a severe toe injury while J.J. McCarthy is out for at least this week due to an injured ankle. Jake Browning, who played well in relief of Burrow in Week 2, will start for the Bengals this week while Carson Wentz gets the nod for Minnesota. Both backups have elite players to throw to on offense, but the injuries don’t stop at the quarterback spot in this one.
The Bengals’ secondary is without one of its two top corners as Cam Taylor-Britt is out. The good news is DJ Turner II, who was questionable, will play. Additionally, first-round edge rusher Shemar Stewart is out.
As for the Vikings, starting center Ryan Kelly is out, but left tackle Christian Darrisaw will suit up after being listed as questionable. Longtime Vikings safety Harrison Smith will also make his 2025 debut.
The Vikings opened as 1.5-point favorites, but that number is now -3. The total has also dropped from 47.5 all the way down to 42.5.
Pittsburgh Steelers at New England Patriots (1 p.m. ET)
The injury focus here is on the defensive side of the ball. The Patriots are again without star cornerback Christian Gonzalez due to a lingering hamstring injury, and he has yet to suit up in 2025. The Steelers are without cornerback Joey Porter Jr. for the second straight week, as well as starting linebacker Alex Highsmith. The good news is Pittsburgh first-round pick Derrick Harmon will make his NFL debut this week after missing the first two games of his rookie campaign.
Lines have stayed steady here, with the Steelers favored by 1.5 on the road and the total sitting at 44.5.
Los Angeles Rams at Philadelphia Eagles (1 p.m. ET)
The Eagles enter this Divisional Round rematch in good shape, with Jalen Carter and Dallas Goedert off the injury report. As for the Rams, they’ll be without starting guard Steve Avila once again, but 2024 rookie standout Braden Fiske will play in Week 3 after being listed as questionable on Friday.
The Eagles are 3.5-point favorites after opening at -4.5, and the total is down from 46.5 to 44.5.
New York Jets at Tampa Bay Buccaneers (1 p.m. ET)
The Jets have a few players out or questionable here, but the biggest name by far is quarterback Justin Fields. After impressing in a Week 1 loss to Pittsburgh, Fields suffered a concussion in the Jets’ Week 2 loss to Buffalo. He won’t play on Sunday, so journeyman Tyrod Taylor gets the nod for Gang Green.
On the other side, boy are the Bucs hurting. Left tackle Tristan Wirfs won’t be back for at least one more week, and the team placed two other starting O-linemen — right tackle Luke Goedeke and right guard Cody Mauch — on injured reserve this week. Receiver Chris Godwin is also at least a week from returning, while defensive tackle Calijah Kancey is joining Goedeke and Mauch on IR.
Standout rookie receiver Emeka Egbuka, who’s tied for the NFL lead in touchdown receptions with three, was questionable to play this week, but he’s active for the Bucs.
Tampa is now -6.5 after opening at -7.5, and the total has dropped from 45.5 to 43.5.
Indianapolis Colts at Tennessee Titans (1 p.m. ET)
Standout rookie tight end Tyler Warren, who has 155 yards already, was listed as questionable for the Colts with a toe injury, but he was taken off the injury report on Saturday and will play on Sunday.
As for Tennessee, right tackle JC Latham is out again, as is big defensive tackle T’Vondre Sweat. Sweat being out is a big deal with the Colts leaning on a run game powered by star back Jonathan Taylor. The Titans will have top cornerback L’Jarious Sneed, who was initially listed as questionable.
The Colts remain 4.5-point favorites on the road, and the total is 43.5.
Las Vegas Raiders at Washington Commanders (1 p.m. ET)
The Commanders will be without 2024 Rookie of the Year Jayden Daniels for at least Week 3 as the second-year signal-caller is out with a knee injury. Daniels played all of Week 2 against Green Bay, where he and Washington struggled offensively. With Daniels out, the Commanders turn to Marcus Mariota.
Washington is a 3-point favorite over the visiting Raiders, and the total is 43.5 after opening at 44.5.
Denver Broncos at Los Angeles Chargers (4:05 p.m. ET)
These two AFC West playoff teams from a year ago are relatively healthy for Week 3. Denver tight end Evan Engram is out for Week 3 for Denver, while linebacker Dre Greenlaw still will not make his 2025 debut. For the Chargers, linebacker Daiyan Henley headlines the team’s injury report as he’s questionable due to illness.
The Chargers are favorites at -3, and the total is up to 46.
New Orleans Saints at Seattle Seahawks (4:05 p.m. ET)
The injuries for this one all come on the Seahawks side of things. Star receiver Jaxon Smith-Njigba was added to the injury report on Saturday due to illness, and he’s listed as questionable. Seattle’s No. 2 back Zach Charbonnet, who scored in Week 1 but was bottled up in Week 2, likely won’t play against New Orleans. Additionally, three of Seattle’s top defensive backs are unlikely to suit up as starting cornerback Devon Witherspoon, starting safety Julian Love and rookie safety Nick Emmanwori are all doubtful as well. Emmanwori and Witherspoon were out for Week 2 while Love played.
Seattle is a 7.5-point favorite at home, and the total is 41.5.
Dallas Cowboys at Chicago Bears (4:25 p.m. ET)
The Cowboys will again be without top cornerback DaRon Bland, but that’s about it for Dallas in terms of injuries.
The same can’t be said for Chicago, which is down three defensive starters in cornerbacks Jaylon Johnson and Kyler Gordon and linebacker TJ Edwards. Additionally, starting running back D’Andre Swift is questionable to suit up.
The Bears opened at -3 at home but find themselves +1.5 after a rough start to the season, which included a blowout loss to Detroit in Week 2. After Dallas scored 40 last week and Chicago allowed 52, the total here is now 50.5 after opening at 47.5.
Arizona Cardinals at San Francisco 49ers (4:25 p.m. ET)
Joe Burrow isn’t the only quarterback dealing with a toe injury. San Francisco’s Brock Purdy missed Week 2 with a toe issue and while he’s officially questionable to suit up for Week 3, he likely won’t start even if he dresses. Head coach Kyle Shanahan told reporters that Purdy is “highly unlikely” to start, so he may back up Mac Jones if he suits up on Sunday. It’s also unclear yet if receiver Jauan Jennings will play as he’s questionable.
Even with injuries piling up, the 49ers are 2-0 and are 3-point favorites, though the total is down from 47.5 at open to 45.5.
Kansas City Chiefs at New York Giants (8:20 p.m. ET)
It looks like Patrick Mahomes could get some reinforcements for this one. The Chiefs were already without top receiver Rashee Rice to start the year due to a suspension, but rookie Jalen Royals has missed the first two weeks of the season while 2024 first-round pick Xavier Worthy missed Week 2 and most of Week 1 after injuring his shoulder in a collision with teammate Travis Kelce. Kansas City’s passing game has gotten off to a slow start, so either Royals or Worthy playing could give the team a boost.
As for the Giants, they lost an overtime thriller in Dallas last week and are 0-2 heading into Sunday Night Football, but Russell Wilson and Co. could get a boost with left tackle Andrew Thomas questionable to play after missing the first two weeks of the season. That’d be a big help, especially against a good, deep Kansas City defensive front.
The line’s stayed steady here, with the Chiefs still favored by six and the total still sitting at 45.
Detroit Lions at Baltimore Ravens (8:15 p.m. ET, Monday)
- BAL TE Isaiah Likely (foot, out)
- BAL OLB Kyle Van Noy (hamstring, out)
- BAL DT Nnamdi Madubuike (neck, out)
- BAT FB Patrick Ricard (calf, out)
- DET OT Taylor Decker (shoulder, questionable)
- DET S Kerby Joseph (knee, questionable)
- DET CB D.J. Reed (knee, questionable)
- DET LB Jack Campbell (ankle, questionable)
- DET DE Marcus Davenport (chest, out)
Both sides are beat up entering this one. Baltimore is without four key players, two each on offense and defense. Offensively, tight end Isaiah Likely and fullback Patrick Ricard will miss their third straight games. Likely has emerged as a key weapon for Lamar Jackson, while Ricard is a vital blocker in the run game. Defensively, two top defensive linemen are out in Kyle Van Noy, who has 21.5 sacks over the last two years, and Nnamdi Madubuike, a two-time Pro Bowler.
Detroit has ruled out starting defensive end Marcus Davenport and has three other defensive starters listed as questionable in cornerback D.J. Reed, safety Kerby Joseph and linebacker Jack Campbell. Additionally, left tackle Taylor Decker is questionable.
The Ravens are now 4.5-point favorites after opening at -3.5, and after these teams combined for more than 90 points last week, the total is up to 53.5 after opening at 49.5.
