Isak has struggled to settle at Liverpool since making the move from Newcastle but his goal on Saturday should have been the moment to really kick-start his season.
Instead this is a seismic blow and one which will have potential consequences going into the January transfer window, with the Reds short of attacking depth.
Mohamed Salah is away at the Africa Cup of Nations and despite uncertainty over his future is unlikely to leave the club in January.
That said, they must plan for life after Salah, who now looks all but set to leave by 2027 when his current deal expires.
Cody Gakpo, who has been inconsistent this season, is currently injured but is set to return next month. Federico Chiesa and Rio Ngumoha have been used sparingly by Slot this season.
Hugo Ekitike has adapted to life on Merseyside brilliantly with 11 goals since signing in the summer and the 23-year-old will continue to lead the line in the absence of Isak.
Liverpool are interested in signing a versatile forward and the obvious target is Bournemouth’s Antoine Semenyo, who can play on both flanks but Manchester City, Manchester United and plenty of others are interested in the 25-year-old. The Ghana international has a £65m release clause that could be activated next month.
Speaking before Isak got injured, Slot said: “The outside world wants to believe we have unlimited money but that is not true.”
Liverpool spent over £415m in the summer, the most by a Premier League club in any transfer window, but they recouped over £187m in sales.
Isak’s injury news will be hugely disappointing for both player and club but Liverpool do have room to spend in January if they decide to.
