The Sunday NFL DFS main slate is approaching, and some of the marquee matchups on the Week 6 NFL schedule are Cardinals vs. Colts, Seahawks vs. Jaguars, Cowboys vs. Panthers and Rams vs. Ravens. In the afternoon window, there is Buccaneers vs. 49ers and Packers vs. Bengals in what could both be fast-paced offensive contests, making them ideal games for NFL DFS players to target. Cowboys vs. Panthers has the highest over/under on the Sunday main slate at 48.5, so that game will be of particular interest to daily Fantasy players.
Which players should you target in your core NFL DFS picks for Week 6 on Sunday, and which potential NFL DFS values could help your NFL DFS lineups cash? Before locking in any NFL DFS picks on sites like DraftKings and FanDuel on Sunday, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.
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McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up.
Now, McClure has turned his attention to Sunday, and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.
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Top NFL DFS picks for Week 6
One of McClure’s top NFL DFS picks for Sunday is Rams wide receiver Puka Nacua, who has an over/under of 8.5 receptions. The former BYU standout delivered a strong showing for the Rams in 2024 despite missing time, hauling in 79 receptions for 990 yards and 3 touchdowns over 11 games. He has picked up right where he left off and hit the ground running in 2025.
Through five games, he has already totaled 52 receptions for 588 yards, both league-highs, and two touchdowns. Nacua leads the NFL in targets (62), reflecting his continued importance in the Rams’ offense, and ranks fourth in the league in yards gained after the catch (214). See who else to roster here.
Part of McClure’s optimal NFL DFS strategy also includes rostering Panthers running back Rico Dowdle. The former undrafted free agent out of South Carolina had a breakout season while playing for the Cowboys in 2024, rushing for 1,079 yards, averaging 4.59 yards-per-carry with two rushing touchdowns. He also chipped in as a receiver with 39 catches for 249 yards and three receiving scores.
In 2025, after signing with the Panthers, he’s gotten off to a solid start, compiling 289 rushing yards on 51 carries and two rushing touchdowns thus far. His efficiency has actually improved in Carolina, with a 5.7 yards-per-carry mark early in the season. With an injury to Carolina’s lead back, Chubba Hubbard, Dowdle stepped up with a massive performance in Week 5, rushing for 206 yards in the Panthers’ comeback win over the Miami Dolphins. See who else to roster here. See who else to roster here.
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How to set NFL DFS lineups for Week 6
McClure is targeting another undervalued player who could explode for huge numbers on Sunday. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, at SportsLine.
So who is Mike McClure including in his optimal NFL DFS lineups for Sunday, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.
